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Гетероиммунные антитела против антигена

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kean university essay help Каково же было удивление исследователей, когда они обнаружили точно такую же пентапептидную структуру и в гомологичных участках (Fc-фрагментах) у2и у3-полипептидных цепей иммуноглобулиновых молекул изотипических подклассов IgG2 и IgG3. J В Natvig source и сотр (1969) путем иммунизации получили гетероиммунные антитела против антигенной детерминантыGm (а—), которые были обозначены авторами антителами анти-«не-а». Одновременно эти же авторы обнаружили гетероиммунные антитела против антигена в фенотипе Gm(g—), обозначенного антигеном «не-g», т.е. антитела анти-«не-д», которые обнаруживали соответствующие антигенные детерминанты в определенных участках у2и Gm(g—) у3-полипептидиых цепей. Антигены этого вида были названы «пе-маркерами» потому, что они в одних изотипических подклассах иммуноглобулинов выступали как изоаитигены (например, «не-a» в подклассах IgG2 и IgG3, «не-g» в подклассе IgG2), а в других изотипических IgG-подклассах проявляли себя в качестве аллотипических enter генетических маркеров например, «не-a» в подклассе IgGi как альтернатива uva essay prompts генетическому маркеру Gm(a), «не-g» в подклассе IgG3 как альтернатива генетическому маркеру Gm(g). V Rutishauser и сотр (1968), а также G М. V Rutishauser и сотр (1968), а также G М. Edelman и сотр (1969) смогли показать, что замещение аминокислот, превращающее «не-маркер» «не-a» в фактор Gm(a), и наоборот, происходит в позициях 356 (Glu->Asp) и 358 (Met->Leu) С-частей тяжелых Н-цепей IgG-молекул. J В Natvig, М W Turner (1971) считают вероятным, что одно из найденных ими антител, реагирующее с антигенными детерминантами у4-полипептидных цепей, связывает маркер, соответствующий гомологичным областям для факторов Gm(a) и «не-a» на уг, у2и у3-полипептидных цепях IgG-молекул.

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pgt english question papers G М Edelman и сотр (1969) обнаружили здесь в позиции субситуацию (замену) аминокислот Arg–Gln.

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